Background:Xenical, a prescription drug, is an oral medicine and is used in more than 80 countries worldwide. It is used to treat obesity, the most common cause of weight gain in adults and a leading cause of chronic disease. The aim of this study was to investigate the efficacy and safety of Xenical in obese patients with type 2 diabetes mellitus (T2DM).
Methods:This multicenter, double-blind, placebo-controlled study was conducted in 27 countries. All patients were initially considered for treatment of obesity in obese patients (BMI ≥27 kg/m2) by an ophthalmologist or an ophthalmologist on referral to a urologist. All patients were randomized to receive a 1-mg dosage of Xenical (Xenical 120 mg) or placebo. Treatment duration was determined by the investigator and the patient information leaflet. The study was conducted on patients who met the inclusion and exclusion criteria. The study was registered in the Internationalobesity Database, in clinicaltrials.gov as XENICAL, and in clinical summary ().
Results:On average, the total study period was 4.6 months with the mean age being 53.8 years. The mean body mass index was 28.9 kg/m2 and the mean HbA1c was 9.2%. The mean patient age was 67.4 years. The mean number of body weight was 7.8 kg and the mean HbA1c was 10.3%.
Conclusion:Xenical, a prescription drug, is an effective and well tolerated treatment for the treatment of obesity in patients with T2DM. The study is of value in the understanding of the role of Xenical in treating obesity in obese patients.
Table 1 Clinical characteristics of patients who received the treatment of Xenical for T2DMThe patients were randomized to receive 1-mg dose of Xenical 120 mg. The median number of body weight was 7.8 kg (range: 3-20 kg), and the mean number of body weight was 10.3 kg. The patients were diagnosed with type 2 diabetes mellitus.
A total of 26 patients were enrolled in the study, of whom 21 met the inclusion and exclusion criteria and were randomized to either the placebo or Xenical.
The mean age of the patients was 56.5 years, and the mean patient BMI was 28.9 kg/m2.
The mean baseline BMI was higher in the Xenical group than in the placebo group (P = 0.037). However, there were no significant differences in weight changes, fasting and postprandial glucose or lipid profiles over the 3 months post-treatment. No serious adverse events were noted.
Figure 1 Flowchart of the study design. (A) Baseline. (B) Xenical treatment. (C) Placebo treatment. (D) Xenical treatment. (E) Placebo group. (F) Placebo treatment. (G) Baseline. X, Xenical; placebo, Xenical 120 mg. P, post-treatment.All patients completed the study and were well-controlled with no serious adverse events. The mean number of follow-up visits was 2.4 years. The patients were not treated with drugs that can cause an adverse reaction. No other complications were noted.
Xenical is a safe and effective treatment for patients with T2DM. This study provides a basis for a better understanding of Xenical's role in treating obesity.
Table 2 Baseline characteristics of patients who received the treatment of Xenical for T2DMThe patients were randomized to either the placebo or Xenical.
The mean baseline BMI was 27.3 kg/m2.
The mean number of body weight was 7.5 kg (range: 3-20 kg) and the mean number of body weight was 9.3 kg (range: 3-20 kg). There were no significant differences in weight changes, fasting and postprandial glucose or lipid profiles over the 3 months post-treatment. There were no serious adverse events.
No other serious adverse events were reported.
(F) Xenical treatment.
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Healthy weight loss
Top tips for healthy weight loss:
To help you find out if you have a healthy body weight, measure your and waist circumference To lose weight, the energy you take in from food must be less than the energy you use – eat less, move more!
Set yourself realistic goals to achieve a healthy weight. Even small amounts of weight loss can have significant health benefits and can help to set you on a path to a healthier future. Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week
Weight loss can reduce your risk of: heart disease, stroke, type 2 diabetes and some cancers.
It can also reduce the risk of:
High blood pressure Angina (heart condition causing chest pain) High blood cholesterol levels Lower back and joint pain Fertility problems BMI and waist circumference
For most adults:
A BMI between 18.5 and 25 is defined as healthy. A BMI of over 25 is defined as overweight. A BMI of over 30 is defined as obese.
Waist-circumferences for which there is an increased risk and high risk of obesity-related health problems:
Increased risk High risk Men ≥94 cm (37 in) ≥102 cm (40 in) Women ≥80 cm (31.5 in) ≥88 cm (34.5 in)
Sensible weight loss should be seen as an overall lifestyle change which involves eating a healthy balanced diet and doing plenty of physical activity.
Guidelines recommend that you should try to lose weight gradually, about 1-2 lbs (approximately 0.5-1.0 kg) a week. This way, the weight is more likely to stay off. This rate of weight loss is based on using up 600 kcal per day more than you take in. On average, this means consuming no more than 1,400 kcal a day if you are a women, and no more than 1,900 kcal a day if you are a man. The amount of weight you lose will depend on how much weight you need to lose and how active you are.
Further information can be found on the manufacturers
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Orlistat.
The majority of unwanted effects related to the use of Orlistat result from its local action in your digestive system. These symptoms are generally mild, occur at the beginning of treatment and are particularly experienced after meals containing high levels of fat. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.
Very common (may affect more than 1 in 10 people):
headache abdominal pain/discomfort urgent or increased need to open the bowels flatulence (wind) with or without discharge oily discharge, oily or fatty stools liquid stools low blood sugar levels (experienced by some people with type 2 diabetes) upper respiratory infections flu (influenza)
Common side effects
The most common side effects of Orlistat are:
1 In 1 person (1 in 10) an allergic reaction to Orlistat was reported. The person should be treated with immediate medical attention.2 In 1 person (1 in 10) an irreversible loss of kidney function was reported.3 An allergic reaction to Orlistat in a severe case was also reported.4 In 1 person (1 in 10) diarrhoea was reported.5 In 1 person (1 in 10) possible suicidal thoughts were also reported.
Xenical is the brand name of an over-the-counter medication that has a very similar mechanism to a branded version of the drug called Orlistat. But this difference is not necessarily a direct effect on people's health. Orlistat blocks about 20% of the fat that people eat, and it's effective in preventing the weight gain you expect from dieting alone. But this drug can also cause other side effects, including liver damage, seizures, and heart attacks. If you have diabetes, your doctor will probably start you on a low-sugar diet and gradually increase your sugar levels. Orlistat is a prescription medication that's approved for use by doctors for weight loss. But if you have an irregular heart or liver problem, you may be prescribed a medication called Phentermine, which is a drug that blocks about 20% of the fat you eat from being absorbed. It's available only by prescription and is sold under the brand name Xenical. If you're a big fan of Xenical, you may already know that it's a very effective and sometimes life-changing drug. But the weight loss pill, especially if it's taken with a meal or snack, can make it hard to keep from gaining more weight. If you're a big fan of Orlistat, you may already know that it's the perfect weight loss pill for you. Orlistat is an FDA-approved prescription medication that's FDA-approved for weight loss. If you're a big fan of Orlistat, you may already know that it's an effective and sometimes life-changing drug. It works by blocking about 20% of the fat that people eat, and it's effective in preventing the weight gain you expect from dieting alone. But this drug can also cause other side effects, including seizures, heart attacks, and liver damage. In fact, it's possible to develop more serious side effects when you use this type of medication. These side effects include: • Weight loss • Allergic reactions • Allergic reactions • Seizures • Liver damage • Heart attack • Stroke • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems
Xenical is a brand name for an over-the-counter medication that works by blocking about 20% of the fat you eat from being absorbed. It's available only by prescription and is FDA-approved for weight loss. It can also cause other side effects, including: • Allergic reactions • Allergic reactions • Seizures • Allergic reactions • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problemsIt can also cause other side effects, including: • Allergic reactions • Allergic reactions • Seizures • Allergic reactions • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problems • Stroke and kidney problemsIt's available only by prescription and FDA-approved for weight loss.XENICAL is a medicine containing the active ingredient orlistat. XENICAL is used to treat obesity and is also used to reduce the risk of developing serious heart and kidney problems. XENICAL belongs to a group of medicines called lipase inhibitors. XENICAL works by preventing the absorption of fat in the body.
XENICAL is available as a prescription medicine and as an over the counter drug. XENICAL is also available in the form of tablets and as a liquid medicine. The medicine must be taken 1 hour before the procedure to make it effective. XENICAL is to be used by and or with a group of people who also have a doctor-patient ratio of one:1. XENICAL is not suitable for use in patients with a doctor-patient ratio of 1:1. XENICAL is not suitable for use in patients with a doctor-patient ratio of 1:1.2 or with a doctor-patient ratio of 2:1. XENICAL is not suitable for use in use in patients with a doctor-patient ratio of 2:1.4. XENICAL is not suitable for use in use in patients with a doctor-patient ratio of 2:1. XENICAL is not suitable for use in use in use in patients with a doctor-patient ratio of 2:1. XENICAL is not suitable for use in use in use in use patients with a doctor-patient ratio of 2:1.2. XENICAL is not suitable for use in use in use use patients with a doctor-patient ratio of 2:1.2. XENICAL is not suitable for use in use use patients with a doctor-patient ratio of 2:1.2. XENICAL is not suitable for use use patients with a doctor-patient ratio of 2:1.2.
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